Lonomia obliqua venom and hemolymph have been shown to contain molecules that, besides interfering in blood coagulation (for a review, Veiga et al. ). Lonomia obliqua (Walker, ) is a moth from the family Saturniidae, widely distributed in tropical rainforests of South America. In its larval stage (caterpillar) it . Rev Assoc Med Bras (). May-Jun;61(3) doi: / Lonomia obliqua Walker (Lepidoptera: Saturniidae): hemostasis .

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Therefore, further studies involving cell culture to investigate the effects of L. When treatments with only forskolin or 8-Br-cAMP are compared to the control, no differences in cell viability is observed Fig. It is famous for its larval form, rather than the adult moth, primarily because of the caterpillar’s defense mechanism, urticating bristles that inject a potentially deadly venom.

The coagulopathy becomes apparent, typically within 48 h after obliqau, presenting with ecchymosis and the bleeding complications described [ 24 ]. These results suggest that the venom components act at different optimal concentrations, therefore the combined effect may vary depending on sample preparation, concentration used and also cell type.

From Wikipedia, the free encyclopedia. Published online Jan Despite an improvement in symptoms, the haematocrit initially continued to fall Views Read Edit View history.

The renal lesion appears to be secondary to massive deposition of fibrin in the glomeruli leading to ischaemia. Physical examination revealed several skin hemorrhages, and gross hematuria was present. Although few oblliqua are recorded, a case study of a fatal encounter was published in Lonomla de Neuro-Psiquiatria: Even though some active principles seem to be concentrated in the spicules, there is no morphological barrier separating these structures from the hemolymph, therefore different venomous preparations may have similar activities Pinto et al.


It is worthy to note that all patients evolved favorably within the first few hours, and for this reason, the use of this antivenom is recommended to treat the cases of Lonomia erucism in Argentina.

Effects of Lonomia obliqua caterpillar venom upon the proliferation and viability of cell lines

After 24 hours, a severe bleeding disorder ensues, leading to ecchymosishematuriapulmonaryand intracranial hemorrhagesand acute renal failure. Doctors were mystified lonomiz scores of patients came in with the same symptoms. A diagnosis of Lonomia toxin poisoning and subsequent acute obliquua injury AKI and coagulopathy was made. Saturniidaewere described.

Two species of Lonomia, the Brazilian caterpillar Lonomia obliqua and the Venezuelan caterpillar Lonomia achelous, provoke activation of the coagulation cascade through the action of several compounds that are the subject of toxicology research [ 2 ].

The first step to verify this difference would be to identify the cellular mechanism activated in fibroblasts that lead these cells to death and try to determine if this same mechanism is activated or not in tumor cells treated with the venom. Caterpillar in Yasuni National ParkEcuador. lonomai

Interestingly, previous studies have shown that a protein from L. MTT analyses indicate that L. The caterpillars are themselves extremely cryptic, blending in against the bark of trees, where the larvae commonly aggregate. While this victim did not die, prompt medical attention was necessary.

The larvae, like most hemileucinesare covered with urticating hairsbut these caterpillars possess a uniquely potent anticoagulant venom. Quite interestingly, we found that the antiapoptotic protein isolated from L.

Author information Article notes Copyright and License information Disclaimer. A non-inflammatory and cytoprotective molecule in neutrophils and endothelial cells”. Losac, a factor X activator obllqua Lonomia obliqua bristle extract: Since the southern Brazilian States have reported accidental poisoning by L.

Lonomia obliqua

Discussion Animal venoms are complex combinations of different active principles, causing diverse effects in human physiology when envenomation occurs. Abstract Many active principles produced by animals, plants and microorganisms have been employed in the development of new drugs for the treatment of human diseases. Both results of this study, either an increase or a decrease in cell proliferation, are important.


They are commonly known as giant silkworm motha name also used for a wide range of other saturniid moths.

[Accidents with caterpillar Lonomia obliqua (Walker, 1855). An emerging problem].

Lonomia obliqua has a toxic venom which causes disseminated intravascular coagulation and a consumptive coagulopathy, which can lead to a hemorrhagic syndrome. National Center for Biotechnology InformationU. In other projects Wikimedia Commons Wikispecies.

The resulting medical syndrome is sometimes called lonomiasis.

Lonomia – Wikipedia

This article was originally published in. On the other hand, active principles that circulate in the hemolymph and therefore are present in the spicules may be inhibited by molecules produced ohliqua only a specific cell type or tissue, leading to the wrong assumption that such an activity is not present in that specific structure.

This anti-clotting agent would attach to another protein of the body’s cells and cause them to leak as blood is unable to clot.

Open in a separate window. Caterpillars of the species L.

Proteases from Lonomia obliqua venomous secretions: The findings of blood obpiqua on arrival were Hb 9. The diagnosis of poisoning is made based on the patient’s medical history, clinical manifestations, erythrocyte levels, and, primarily, parameters that evaluate blood coagulation.